Project Description
Using multiomics, flow cytometry, and functional studies, I discovered a T-cell acute lymphoblastic leukemia (T-ALL) subtype dependent on MYCN. Building upon preliminary results that suggest an important role of H3K4 methylation in controlling MYCN gene expression in these leukemias, my present research seeks to identify the key epigenetic modifiers responsible for establishing or maintaining H3K4 methylation in the context of T-ALL development. Ultimately, this investigation may unveil novel pharmacological targets for better combating specific subtypes of T-ALL.
Research Classification
- Mechanisms of carcinogenesis
- Cancer drug development and therapeutics
- Basic pharmacology
- Applied immunology (including antibody engineering, xenotransplantation and t-cell therapies)
Research Interests
- hematology
- oncology
- Inflammation
- Epigenetics
Research Methodology
- RNA-Seq
- ChIP-seq
- High-parameter Flow Cytometry
- Primary Cell Culture
- Human Synthetic T-ALL model
- in-vivo testing
Faculty
Faculty of Medicine